D. E. Shaw Research (DESRES) is a New York?based independent research laboratory that conducts scientific research in the field of computational biochemistry. Our group is currently focusing primarily on long molecular dynamics (MD) simulations involving proteins and other biological macromolecules of potential interest from both a scientific and a pharmaceutical perspective. An integral part of our effort consists of designing and developing custom hardware and software to carry out this research. We are also pursuing drug discovery programs, leveraging the insights enabled by our novel technologies, with an initial focus on drug targets that have proved resistant to traditional drug discovery methods. Our team includes computational chemists and biologists, computer scientists and applied mathematicians, and computer architects and engineers, all working collaboratively within a tightly coupled interdisciplinary research environment under the leadership of our chief scientist David Shaw.